Sodium ethoxide → 4-[2-(1-Ethyl-4,5-dihydro-imidazol-2-yl)ethyl]-pyridine

HRID 485809

반응식

HRID 485809 반응식
[C:1]([CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][N:8]=[CH:7][CH:6]=1)#N.C1(C)C=CC(S(O)(=O)=O)=CC=1.[CH2:22]([NH:24][CH2:25][CH2:26][NH2:27])[CH3:23].[O-]CC.[Na+]>C(O)C>[CH2:22]([N:24]1[CH2:25][CH2:26][N:27]=[C:1]1[CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][N:8]=[CH:7][CH:6]=1)[CH3:23]

참가 물질

5

반응물 3

HCID 2723922Sodium ethoxideHCID 73304614-PyridinepropanenitrileHCID 20239798N-ethyl-1,2-diaminoethane mono-p-toluenesulfonate

생성물 1

HCID 137267364-[2-(1-Ethyl-4,5-dihydro-imidazol-2-yl)ethyl]-pyridine수율 60%

시약·촉매·용매 1

HCID 702Ethanol용매2회

반응 조건

온도
190 °C

실험 절차

A mixture of 4-(2-cyanoethyl)pyridine (1.32 g, 0.01M) and N-ethyl-1,2-diaminoethane mono-p-toluenesulfonate (5.5 g, 0.02M) were heated at 190° C. for 4 hrs under nitrogen. The reaction mixture was dissolved in ethanol (30 ml) and sodium ethoxide (0.02M) in ethanol (50 ml) was added. The mixture was filtered and the filtrate was stripped to dryness and distilled at 130° C./0.2 mmHg to yield 4-[2-(1-ethyl-4,5-dihydro-imidazol-2-yl)ethyl]-pyridine (1.2 g, 60% yield).

후처리

  1. filtrationThe mixture was filtered
  2. distillationdistilled at 130° C./0.2 mmHg

출처 및 근거

ORD 기록
ord-4c2555b3c17d415e93a0b6b88e44caf0
출처 데이터셋
uspto-grants-1985_08
특허 번호
US04537969

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