Ammonia → 2-(6-Methoxy-2-naphthyl)propanamide

HRID 485978

반응식

HRID 485978 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([CH:13]([CH3:17])[C:14](Cl)=[O:15])[CH:7]=[CH:6]2.[NH3:18]>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([CH:13]([CH3:17])[C:14]([NH2:18])=[O:15])[CH:7]=[CH:6]2

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 101988292-(6-methoxynaphthalen-2-yl)propanoyl Chloride

생성물 1

HCID 6040272-(6-Methoxy-2-naphthyl)propanamide

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

Into 300 ml of dry toluene, were dissolved 10.8 g of oa (6-methoxy-2-naphthyl)-propanoic acid chloride, followed by introducing dry ammonia at a temperature not more than 15° C. for 30 minutes. Stirring was continued at room temperature for 3 hours, and then precipitated while solid was filtered off. The resulting white solid was washed with toluene and then water, followed by recrystallizing with ethanol to obtain 10.0 g of oa (6-methoxy-2-naphthyl)-propanamide.

후처리

  1. customprecipitated while solid
  2. filtrationwas filtered off
  3. washThe resulting white solid was washed with toluene
  4. customby recrystallizing with ethanol

출처 및 근거

ORD 기록
ord-49af79d916fb43db9acd673d5863e51e
출처 데이터셋
uspto-grants-1994_03
특허 번호
US05290478

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