참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | Dimethyl methoxymalonate | HCID 78718 | — |
| 반응물 | Sodium Methoxide | HCID 10942334 | — |
| 반응물 | 4-(Benzyloxy)benzene-1-carboximidamide hydrochloride | HCID 11242483 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | HCID 178493927 | HCID 178493927 | 61.2% |
반응 단계
A mixture of 85 g of 4-benzyloxybenzamidine hydrochloride, 78.6 g of dimethyl methoxymalonate, 1700 ml of ethanol, and 187 g of sodium methylate (28% methanol solution) was heated at 80° C. for 4 hours with stirring. After cooling, 1000 ml of acetic acid was slowly added to the reaction mixture, whereupon a yellow crystal precipitated. The precipitated crystals were collected by filtration, washed twice with water until the washing became neutral, and dried at 80° C. for 3 hours in high vacuo to obtain 64.2 g (percent yield: 60.7% ) of 4,6-dihydroxy-5-methoxy-2-(4-benzyloxyphenyl)pyrimidine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05290477 |
|---|
| 출처 데이터셋 | uspto-grants-1994_03 |
|---|
| ORD ID | ord-0676444237ca42619673ba1254c32ac4 |
|---|
| 출처 메모 | uspto-grants-1994_03 |
|---|
