Potassium Carbonate → 3-[(4-Bromophenyl)methyl]-2-butyl-6-(1-hydroxy-1-methylethyl)-4(3H)-quinazolinone

HRID 486034노트

반응식

HRID 486034 반응식
[CH2:1]([C:5]1[NH:6][C:7]2[C:12]([C:13](=[O:15])[N:14]=1)=[CH:11][C:10]([C:16]([OH:19])([CH3:18])[CH3:17])=[CH:9][CH:8]=2)[CH2:2][CH2:3][CH3:4].[Br:20][C:21]1[CH:28]=[CH:27][C:24]([CH2:25]Br)=[CH:23][CH:22]=1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[Br:20][C:21]1[CH:28]=[CH:27][C:24]([CH2:25][N:14]2[C:13](=[O:15])[C:12]3[C:7](=[CH:8][CH:9]=[C:10]([C:16]([OH:19])([CH3:18])[CH3:17])[CH:11]=3)[N:6]=[C:5]2[CH2:1][CH2:2][CH2:3][CH3:4])=[CH:23][CH:22]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 685274-Bromobenzyl bromideHCID 178441842HCID 178441842, 화합물

생성물 1

HCID 200793443-[(4-Bromophenyl)methyl]-2-butyl-6-(1-hydroxy-1-methylethyl)-4(3H)-quinazolinone

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a solution of 1.37 g of 2-butyl-6-(1-hydroxy-1-methylethyl)-4(1H)-quinazolinone in 115 ml of acetone is added 1.58 g of 4-bromobenzyl bromide and 2.18 g of anhydrous potassium carbonate. The resulting suspension is heated to reflux for 16 hours. The reaction mixture is then allowed to cool to room temperature, filtered and the filtrate is concentrated vacuo. The residue is purified by HPLC eluting with ethyl acetate/hexanes (1:3) to provide the desired product.

후처리

  1. temperatureThe resulting suspension is heated
  2. temperatureto reflux for 16 hours
  3. filtrationfiltered
  4. concentrationthe filtrate is concentrated vacuo
  5. customThe residue is purified by HPLC
  6. washeluting with ethyl acetate/hexanes (1:3)

출처 및 근거

ORD 기록
ord-cd499bd4835a49149217c6ea7eb975dd
출처 데이터셋
uspto-grants-1994_03
특허 번호
US05290780

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