Ethyl Acetate → HCID 53909511, 화합물

HRID 486062노트

반응식

HRID 486062 반응식
[CH2:1]([C:3]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:12]C)[CH:10]=2)[NH:5][C:4]=1[CH2:14][CH2:15][CH3:16])[CH3:2].C(=O)(O)[O-].[Na+].C(OCC)(=O)C>C(O)(=O)C.Br>[CH2:1]([C:3]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([OH:12])[CH:10]=2)[NH:5][C:4]=1[CH2:14][CH2:15][CH3:16])[CH3:2]

참가 물질

5

반응물 3

HCID 8857Ethyl AcetateHCID 516892Sodium BicarbonateHCID 19097339HCID 19097339, 화합물

생성물 1

HCID 53909511HCID 53909511, 화합물수율 98.8%

시약·촉매·용매 1

HCID 21893785Acetic Acid Mixture with Hydrobromic Acid용매

실험 절차

3-Ethyl-5-methoxy-2-propyl indole (2.92 g) in 15 ml of hydrogen bromide acetic acid solution was heated at 100° C. for 4 hours. The cooled solution was poured into an aqueous sodium bicarbonate solution (100 ml) and ethyl acetate with stirring. The separated organic layer was washed with water, dried over magnesium sulfate, and concentrated in vacuo. The crude product was chromatographed on silica gel using 30% ethyl acetate in n-hexanes as eluent to yield 3-ethyl-5-hydroxy-2-propyl indole (2.7 g).

후처리

  1. washThe separated organic layer was washed with water
  2. dry with materialdried over magnesium sulfate
  3. concentrationconcentrated in vacuo
  4. customThe crude product was chromatographed on silica gel using 30% ethyl acetate in n-hexanes as eluent

출처 및 근거

ORD 기록
ord-be1364ea0d074675ac990b494bfe3819
출처 데이터셋
uspto-grants-1994_03
특허 번호
US05290788

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