4-Toluenesulfonyl chloride → 5-methyl-1-tosyl-1H-imidazole-4-carbaldehyde

HRID 486219

반응식

HRID 486219 반응식
[CH3:1][C:2]1[NH:6][CH:5]=[N:4][C:3]=1[CH:7]=[O:8].C(N(CC)CC)C.[C:16]1([CH3:26])[CH:21]=[CH:20][C:19]([S:22](Cl)(=[O:24])=[O:23])=[CH:18][CH:17]=1>CN(C)C=O.O.CO>[CH3:1][C:2]1[N:6]([S:22]([C:19]2[CH:20]=[CH:21][C:16]([CH3:26])=[CH:17][CH:18]=2)(=[O:24])=[O:23])[CH:5]=[N:4][C:3]=1[CH:7]=[O:8]

참가 물질

7

반응물 3

HCID 73974-Toluenesulfonyl chlorideHCID 8471TriethylamineHCID 27958875-Methyl-1H-imidazole-4-carbaldehyde

생성물 1

HCID 150519515-methyl-1-tosyl-1H-imidazole-4-carbaldehyde수율 83.9%

시약·촉매·용매 3

HCID 887Methanol용매HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

To a suspension of 5-methyl-1H-imidazole-4-carbaldehyde (20 g) in N,N-dimethylformamide (100 ml) was added triethylamine (20.5 g) and p-toluenesulfonyl chloride (38 g). The mixture was stirred under ice-cooling for two hours. The reaction mixture was diluted with water (600 ml) and separated organic layer was filtered. The residue obtained was suspended in methanol (100 ml). After being stirred at ambient temperature for two hours, the mixture was cooled and filtered to give 5-methyl-1-tosyl-1H-imidazole-4-carbaldehyde (40.3 g).

후처리

  1. temperaturecooling for two hours
  2. customseparated organic layer
  3. filtrationwas filtered
  4. customThe residue obtained
  5. stirringAfter being stirred at ambient temperature for two hours
  6. temperaturethe mixture was cooled
  7. filtrationfiltered

출처 및 근거

ORD 기록
ord-da4887896f4b4fe3b48ad314ed9cc3a3
출처 데이터셋
uspto-grants-1994_03
특허 번호
US05290785

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