Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonium Chloride → 4-(4-n-Propylphenyl)trifluorotoluene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonium Chloride | HCID 25517 | — |
| 반응물 | Benzene, 1-bromo-4-(trifluoromethyl)- | HCID 67872 | — |
| 반응물 | 1-Bromo-4-propylbenzene | HCID 136374 | — |
| 반응물 | Magnesium | HCID 5462224 | — |
| 촉매 | Zinc bromide | HCID 10421208 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4-(4-n-Propylphenyl)trifluorotoluene | HCID 14985193 | — |
반응 단계
11.2 g of anhydrous zinc bromide in 25 ml of THF are added dropwise at about 0° to a Grignard solution prepared from 20 g of 4-n-propylbromobenzene and 2.4 g of magnesium turnings in 100 ml of THF. After the mixture has been stirred for 2 hours, a mixture of 22.5 g of 4-bromotrifluorotoluene, 1.5 g of [(diphenylphosphine)ferrocenyl]palladium(II) chloride and 25 ml of THF is added dropwise, and the mixture is stirred for 24 hours at room temperature and poured into 100 ml of saturated ammonium chloride solution. Customary work-up gives 4-(4-n-propylphenyl)trifluorotoluene, M.p. 97° C., Δε=14.2, viscosity η (20° C.)=6 mm2 /s.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05292454 |
| 출처 데이터셋 | uspto-grants-1994_03 |
| ORD ID | ord-9a287455070b4912bc1db937bf0676e8 |
| 출처 메모 | uspto-grants-1994_03 |