Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sulfuric Acid → 1-(2,4,6-Trimethylphenyl)piperazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sulfuric Acid | HCID 1118 | — |
| 반응물 | Ammonium Hydroxide | HCID 14923 | — |
| 반응물 | 1-Mesityl-4-[(4-methylphenyl)sulfonyl]piperazine | HCID 16645603 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 1-(2,4,6-Trimethylphenyl)piperazine | HCID 2760822 | 69% |
반응 단계
To a stirred mixture of 180 parts of 1-[(4-methylphenyl)sulfonyl]-4-(2,4,6-trimethylphenyl)piperazine and 450 parts of water were added dropwise 675 parts of sulfuric acid. The whole was stirred and refluxed for 4 hours. After cooling, the whole was treated with an ammonium hydroxide solution. The product was extracted with dichloromethane. The extract was dried, filtered and evaporated, yielding 70 parts (69%) of 1-(2,4,6-trimethylphenyl)piperazine as a residue (intermediate 14).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05292738 |
| 출처 데이터셋 | uspto-grants-1994_03 |
| ORD ID | ord-9c3e9e9c6f994e3997e6d57254668174 |
| 출처 메모 | uspto-grants-1994_03 |