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1-(3-(Trifluoromethyl)phenyl)piperazine → HCID 15124559, 화합물

HRID 486451
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인쇄 미리보기

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HRID 486451 반응식
F[C:2]1[N:3]=[N:4][C:5]([F:8])=[CH:6][CH:7]=1.[F:9][C:10]([F:24])([F:23])[C:11]1[CH:12]=[C:13]([N:17]2[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]2)[CH:14]=[CH:15][CH:16]=1.C(=O)([O-])[O-].[Na+].[Na+].CN(C)C=O>O>[F:8][C:5]1[N:4]=[N:3][C:2]([N:20]2[CH2:19][CH2:18][N:17]([C:13]3[CH:14]=[CH:15][CH:16]=[C:11]([C:10]([F:23])([F:24])[F:9])[CH:12]=3)[CH2:22][CH2:21]2)=[CH:7][CH:6]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 42961-(3-(Trifluoromethyl)phenyl)piperazineHCID 6228DimethylformamideHCID 10340Sodium CarbonateHCID 141761Pyridazine, 3,6-difluoro-

생성물 1

HCID 15124559HCID 15124559, 화합물수율 46%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
60 °C

실험 절차

A mixture of 2.7 parts of 3,6-difluoropyridazine, 4.6 parts of 1-[3-(trifluoromethyl)phenyl]piperazine, 3.2 parts of sodium carbonate and 90 parts of N,N-dimethylformamide was stirred overnight at 60° C. The reaction mixture was poured into water. The product was filtered off, washed with water and crystallized from 2-propanol, yielding 3 parts (46%) of 3-fluoro-6-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]pyridazine; mp. 131.5° C. (compound 24).

후처리

  1. filtrationThe product was filtered off
  2. washwashed with water
  3. customcrystallized from 2-propanol

출처 및 근거

ORD 기록
ord-9dc497309ddd4f448193ad695f58e3f5
출처 데이터셋
uspto-grants-1994_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05292738

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