HCID 178418573, 화합물 → HCID 178441847, 화합물

HRID 486490노트

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HRID 486490 반응식
[CH2:1]([C:5]1[NH:6][C:7]2[C:12]([C:13](=[O:15])[N:14]=1)=[CH:11][C:10]([CH:16]=[O:17])=[CH:9][CH:8]=2)[CH2:2][CH2:3][CH3:4].[CH3:18][Mg]Br>O1CCCC1.C(OCC)C>[CH2:1]([C:5]1[NH:6][C:7]2[C:12]([C:13](=[O:15])[N:14]=1)=[CH:11][C:10]([CH:16]([OH:17])[CH3:18])=[CH:9][CH:8]=2)[CH2:2][CH2:3][CH3:4]

참가 물질

5

반응물 2

HCID 178418573HCID 178418573, 화합물HCID 178441857HCID 178441857, 화합물

생성물 1

HCID 178441847HCID 178441847, 화합물

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 8028Tetrahydrofuran용매

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온도
0 °C

실험 절차

To a solution of 0.60 g of 2-butyl-1,4-dihydro-4-oxo-6-quinazolinecarboxaldehyde in 30 ml of dry tetrahydrofuran, cooled to 0° C. is added dropwise, 2.61 ml of a 3.0M solution of methylmagnesium bromide in diethyl ether. The reaction is stirred at 0° C. for 30 minutes and then quenched with 10 ml of aqueous ammonium chloride. After diluting with 10 ml of water, the reaction mixture is extracted with 9:1 chloroformmethanol. The combined extracts are dried with magnesium sulfate, filtered and concentrated to yield 0.64 g of the desired product.

후처리

  1. additionis added dropwise
  2. customquenched with 10 ml of aqueous ammonium chloride
  3. additionAfter diluting with 10 ml of water
  4. extractionthe reaction mixture is extracted with 9:1 chloroformmethanol
  5. dry with materialThe combined extracts are dried with magnesium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-5c98242e7f7a44928799fca92bdff278
출처 데이터셋
uspto-grants-1994_03
특허 번호
US05292734

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