Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diethyl bromomalonate → p-t-butyl-N-[6-chloro-5-(m-methoxyphenoxy)-4-pyrimidinyl]benzenesulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diethyl bromomalonate | HCID 69637 | — |
| 반응물 | 5-(m-methoxyphenoxy)-6-hydroxy-4(3H)-pyrimidinone | HCID 19095757 | — |
| 반응물 | 4,6-Dichloro-5-(3-methoxyphenoxy)-pyrimidine | HCID 19432653 | — |
| 반응물 | Sodium m-methoxyphenolate | HCID 23694484 | — |
| 반응물 | Diethyl (m-methoxyphenoxy)malonate | HCID 53682937 | — |
| 반응물 | p-t-Butylbenzenesulfonamide potassium | HCID 66748434 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | p-t-butyl-N-[6-chloro-5-(m-methoxyphenoxy)-4-pyrimidinyl]benzenesulfonamide | HCID 15391273 | — |
반응 단계
Diethyl bromomalonate was converted with sodium m-methoxyphenolate in analogy to Example 1, paragraph c), into diethyl (m-methoxyphenoxy)malonate, colorless liquid. B.p. 143° C./0.05 Torr. The thus-obtained malonic ester was converted in analogy to Example 1, paragraph d), into 5-(m-methoxyphenoxy)-6-hydroxy-4(3H)-pyrimidinone from which in analogy to Example 1, paragraph e), there was prepared 4,6-dichloro-5-(m-methoxyphenoxy)pyrimidine, m.p. 109°-110° C. Reaction of the last-named compound with p-t-butylbenzenesulfonamide potassium yielded p-t-butyl-N-[6-chloro-5-(m-methoxyphenoxy)-4-pyrimidinyl]benzenesulfonamide, m.p. 152° C. (from methanol).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05292740 |
| 출처 데이터셋 | uspto-grants-1994_03 |
| ORD ID | ord-5a23d08ba3bf4de98972b29c2b52927f |
| 출처 메모 | uspto-grants-1994_03 |