Ammonia → 4-Amino-6-chloro-5-(o-methoxyphenoxy)pyrimidine

HRID 486656노트

반응식

HRID 486656 반응식
[NH3:1].[Cl:2][C:3]1[C:8]([O:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[O:16][CH3:17])=[C:7](Cl)[N:6]=[CH:5][N:4]=1>C(O)C>[NH2:1][C:7]1[C:8]([O:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[O:16][CH3:17])=[C:3]([Cl:2])[N:4]=[CH:5][N:6]=1

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 158191304,6-Dichloro-5-(2-methoxyphenoxy)pyrimidine

생성물 1

HCID 190957014-Amino-6-chloro-5-(o-methoxyphenoxy)pyrimidine

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
-78 °C

실험 절차

105 ml of ammonia were passed into a solution of 7 g of 4,6-dichloro-5-(o-methoxyphenoxy)pyrimidine in 140 ml of ethanol at -78° C. The reaction mixture was stirred for 15 hours at -78° C. and for 50 hours at room temperature and then concentrated. The residue was distributed between ethyl acetate and water and the organic phase worked up. There were obtained 6.45 g of 4-amino-6-chloro-5-(o-methoxyphenoxy)pyrimidine as white crystals.

후처리

  1. concentrationconcentrated

출처 및 근거

ORD 기록
ord-9222b22acdea483785a68ce52229c18e
출처 데이터셋
uspto-grants-1994_03
특허 번호
US05292740

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