HCID 19096630, 화합물 → HCID 12711612, 화합물

HRID 486853노트

반응식

HRID 486853 반응식
[Cl:1][CH2:2][C:3]1[O:8][C:7](=[O:9])[CH2:6][CH2:5][CH:4]=1>[C].[Pd].C(OCC)(=O)C>[Cl:1][CH2:2][CH:3]1[O:8][C:7](=[O:9])[CH2:6][CH2:5][CH2:4]1

참가 물질

4

반응물 1

HCID 19096630HCID 19096630, 화합물

생성물 1

HCID 12711612HCID 12711612, 화합물수율 96%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 8857Ethyl Acetate용매2회

실험 절차

A mixture of 150 mg (1.024 mmol) of (-)-6-chloromethyldihydropyran-2-one obtained in Example 4, 6 ml of ethyl acetate and 60 mg of 10% palladium-carbon was stirred for 2 hours under hydrogen atmosphere. After completion of the reaction, the catalyst was removed by filtration, and the solvent was distilled off. Afterward, the resultant residue was subjected to column chromatography (an eluent of hexane:ethyl acetate=5:1), thereby obtaining 146 mg (yield 96%) of (-)-6-chloromethyltetrahydropyran-2-one having

후처리

  1. customAfter completion of the reaction
  2. customthe catalyst was removed by filtration
  3. distillationthe solvent was distilled off

출처 및 근거

ORD 기록
ord-e7c9c0401dd84bdc93bb8e680c2a9deb
출처 데이터셋
uspto-grants-1994_03
특허 번호
US05292891

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