Water → 2-(Benzo[d][1,3]dioxol-5-yl)propan-2-ol

HRID 486888

반응식

HRID 486888 반응식
[CH3:1][Li].[C:3]([C:6]1[CH:14]=[CH:13][C:9]2[O:10][CH2:11][O:12][C:8]=2[CH:7]=1)(=[O:5])[CH3:4].O>O1CCCC1>[O:10]1[C:9]2[CH:13]=[CH:14][C:6]([C:3]([OH:5])([CH3:1])[CH3:4])=[CH:7][C:8]=2[O:12][CH2:11]1

참가 물질

5

반응물 3

HCID 962WaterHCID 76622AcetopiperoneHCID 178418348HCID 178418348, 화합물

생성물 1

HCID 118196322-(Benzo[d][1,3]dioxol-5-yl)propan-2-ol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

반응 조건

온도
-20 °C

실험 절차

About 600 ml of 1.5M methyllithium (solution in ether) was added to 500 ml of tetrahydrofuran. A suspension of 93.45 g of 5-acetyl-1,3-benzodioxole in 900 ml of tetrahydrofuran was added thereto under cooling at -20° C. The mixture was stirred under these conditions for 1 h. Water was added to the reaction mixture. The product was extracted with ethyl acetate, washed with a saturated aqueous common salt solution and dried over anhydrous magnesium sulfate. After filtration, the filtrate was concentrated to obtain 97 g of the intended compound in the form of an oil.

후처리

  1. additionwas added
  2. extractionThe product was extracted with ethyl acetate
  3. washwashed with a saturated aqueous common salt solution
  4. dry with materialdried over anhydrous magnesium sulfate
  5. filtrationAfter filtration
  6. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-d359b559f57a4cdc9504feb94d8a3821
출처 데이터셋
uspto-grants-1994_03
특허 번호
US05292901

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