3,4-dihydro-5,7-dimethylnaphthalen-1(2H)-one → 1-Hydroxy-1,5,7-trimethyl-1,2,3,4-tetrahydronaphthalene

HRID 487119

반응식

HRID 487119 반응식
[CH3:1][C:2]1[CH:11]=[C:10]([CH3:12])[CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][CH2:6][C:7]2=[O:13].[CH3:14][Mg]Br>CCOCC>[OH:13][C:7]1([CH3:14])[C:8]2[C:3](=[C:2]([CH3:1])[CH:11]=[C:10]([CH3:12])[CH:9]=2)[CH2:4][CH2:5][CH2:6]1

참가 물질

4

반응물 2

HCID 836193,4-dihydro-5,7-dimethylnaphthalen-1(2H)-oneHCID 178418573HCID 178418573, 화합물

생성물 1

HCID 157517571-Hydroxy-1,5,7-trimethyl-1,2,3,4-tetrahydronaphthalene수율 97%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

Following the procedure of Example 1, step 1, 25.20 g (0.145 ml) of 5,7-dimethyltetralone in 200 ml of anhydrous ether was reacted with 60.3 ml of 3.0M methyl magnesium bromide in ether to give 26.64 g (97%) of the title product as an orange oil. NMR δ(CDCl3) 1.56 (3H, s), 1.70 (1H, s), 1.78-2.04 (4H, m), 2.20 (3H, s), 2.30 (3H, s), 2.60 (2H, m), 6.90 (1H, s), 7.30 (1H, s).

출처 및 근거

ORD 기록
ord-95fc79b049ad434296fc1e68dd63124e
출처 데이터셋
uspto-grants-1994_03
특허 번호
US05294618

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