Piperidine → 1-Acetyl-4-(4-piperidinobenzoylmethyl)piperidine

HRID 487163노트

반응식

HRID 487163 반응식
[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([CH2:10][C:11](=[O:19])[C:12]2[CH:17]=[CH:16][C:15](F)=[CH:14][CH:13]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[NH:20]1[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1>C(=O)([O-])O.[Na+]>[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([CH2:10][C:11](=[O:19])[C:12]2[CH:17]=[CH:16][C:15]([N:20]3[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)=[CH:14][CH:13]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

참가 물질

4

반응물 2

HCID 8082PiperidineHCID 100841181-Acetyl-4-(4-fluorobenzoylmethyl)piperidine

생성물 1

HCID 193909281-Acetyl-4-(4-piperidinobenzoylmethyl)piperidine

시약·촉매·용매 1

HCID 516892Sodium Bicarbonate용매

반응 조건

온도
100 °C

실험 절차

A mixture consisting of 1.84 g of 1-acetyl-4-(4-fluorobenzoylmethyl)piperidine and 5 ml of piperidine was stirred under heating at 100° C. for 20 hours. After completion of the reaction, the reaction mixture was diluted with a saturated aqueous solution of sodium hydrogen carbonate and extracted with ethyl acetate. After drying, the solvent was ditilled off and the oily residue was purified by silica gel column chromatography (eluent: ehtyl acetate) to give 2.2 g of a pale yellow oil.

후처리

  1. customAfter completion of the reaction
  2. extractionextracted with ethyl acetate
  3. customAfter drying
  4. customthe oily residue was purified by silica gel column chromatography (eluent: ehtyl acetate)

출처 및 근거

ORD 기록
ord-b07a53c531c14b9eac21ba8f5bc91767
출처 데이터셋
uspto-grants-1994_03
특허 번호
US05294625

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