Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
tert-Butyldimethylsilyl chloride → (-)-(1R,2S)-2-phenyl-1-cyclohexyl triisopropylsilyloxyacetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| 반응물 | Triisopropylsilyl chloride | HCID 139400 | — |
| 반응물 | (-)-(1R,2S)-2-phenyl-1-cyclohexyl hydroxyacetate | HCID 10059921 | — |
| 반응물 | HCID 16770157 | HCID 16770157 | — |
| 반응물 | (+)-(1S,2R)-2-phenyl-1-cyclohexyl hydroxyacetate | HCID 67834441 | — |
| 생성물 | (-)-(1R,2S)-2-phenyl-1-cyclohexyl triisopropylsilyloxyacetate | HCID 10000489 | — |
반응 단계
In the same manner, 1a, 1b, and 1c(+) were prepared from the combinations of (-)-menthyl hydroxyacetate with tertbutyldimethylsilyl chloride, (-)-(1R,2S)-2-phenyl-1-cyclohexyl hydroxyacetate with tert-butyldimethylsilyl chloride, and (+)-(1S,2R)-2-phenyl-1-cyclohexyl hydroxyacetate with triisopropylsilyl chloride, respectively, in 90-95% yields.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05294737 |
| 출처 데이터셋 | uspto-grants-1994_03 |
| ORD ID | ord-1860fbc21a774caa8f042fe51c35ad03 |
| 출처 메모 | uspto-grants-1994_03 |