Formaldehyde → 6-Acetoxy-2-methylene-hexanal

HRID 487483

반응식

HRID 487483 반응식
[C:1]([O:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH:10]=[O:11])(=[O:3])[CH3:2].[Cl-].[CH3:13][NH2+]C.C=O>>[C:1]([O:4][CH2:5][CH2:6][CH2:7][CH2:8][C:9](=[CH2:13])[CH:10]=[O:11])(=[O:3])[CH3:2]

참가 물질

4

반응물 3

HCID 712FormaldehydeHCID 69174896-Oxohexyl acetateHCID 12954980Dimethylazanium;chloride

생성물 1

HCID 189915606-Acetoxy-2-methylene-hexanal

실험 절차

16 g (101.1 mmol) of 6-acetoxyhexanal, 9.2 g (113 mmol) of dimethylammonium chloride and 9.2 ml (118.3 mmol) of a 37% solution of formaldehyde are stirred for 1 hour at a bath temperature of 110° C. The mixture is allowed to cool and extracted three times with CH2Cl2. The combined organic phases are dried over Na2SO4, filtered, and concentrated by evaporation giving 6-acetoxy-2-methylene-hexanal as a slightly yellowish oil which is further reacted without purification.

후처리

  1. temperatureto cool
  2. extractionextracted three times with CH2Cl2
  3. dry with materialThe combined organic phases are dried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated by evaporation

출처 및 근거

ORD 기록
ord-1a81ca3a78c047d1b92a8006c8588c20
출처 데이터셋
uspto-grants-1994_03
특허 번호
US05294734

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