Formaldehyde → 4-Acetoxy-2-methylene-pentanal

HRID 487502노트

반응식

HRID 487502 반응식
[C:1]([O:4][CH:5]([CH3:10])[CH2:6][CH2:7][CH:8]=[O:9])(=[O:3])[CH3:2].[Cl-].[CH3:12][NH2+]C.C=O>>[C:1]([O:4][CH:5]([CH3:10])[CH2:6][C:7](=[CH2:12])[CH:8]=[O:9])(=[O:3])[CH3:2]

참가 물질

4

반응물 3

HCID 712FormaldehydeHCID 111054874-AcetoxypentanalHCID 12954980Dimethylazanium;chloride

생성물 1

HCID 189915204-Acetoxy-2-methylene-pentanal수율 93.9%

실험 절차

18.0 g (124.8 mmol) of 4-acetoxypentanal, 11.5 g (140.7 mmol) of dimethylammonium chloride and 11.0 ml (146 mmol) of a 37% solution of formaldehyde are stirred for 1 hour at a bath temperature of 110° C. The reaction mixture is allowed to cool and then extracted three times with CH2Cl2. The combined organic phases are dried over MgSO4, filtered and concentrated by evaporation, giving 18.3 g of 4-acetoxy-2-methylene-pentanal as a colourless oil which is further reacted without purification.

후처리

  1. temperatureto cool
  2. extractionextracted three times with CH2Cl2
  3. dry with materialThe combined organic phases are dried over MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated by evaporation

출처 및 근거

ORD 기록
ord-47ad611dbab74bd4bdf5fa0387482c46
출처 데이터셋
uspto-grants-1994_03
특허 번호
US05294734

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