Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Bromo-4-fluorobenzene → Ethyl 4-(4-fluorophenyl)benzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Bromo-4-fluorobenzene | HCID 9993 | — |
| 반응물 | Ethyl 4-bromobenzoate | HCID 22043 | — |
| 생성물 | Ethyl 4-(4-fluorophenyl)benzoate | HCID 11989650 | — |
반응 단계
Using the procedure of Example 551, 4-bromofluorobenzene (1.75 g, 10 mmol) was metallated and coupled with ethyl 4-bromobenzoate (2.28 g, 10 mmol) to give the title compound after chromatography (ethyl acetate-hexanes (1:9) (0.7 g)): 1H-NMR (CDCl3, 300 MHz): 8.1 (d, 2H, J=8), 7.65-7.5 (m, 4H), 7.15 (t, 2H, J=8), 4.4 (q, 2H, J=7), 1.4 (t, 3H, J=7); MS:244.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05296479 |
| 출처 데이터셋 | uspto-grants-1994_03 |
| ORD ID | ord-01361a4d6872484085e6c6859c429ebf |
| 출처 메모 | uspto-grants-1994_03 |