1-(4-Nitrophenyl)piperazine → N-[1-(4-Cyanophenyl)-4-piperidinyl)-N'-(4-nitrophenyl)piperazine

반응식

[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:14][CH2:13][C:12](=O)[CH2:11][CH2:10]2)=[CH:5][CH:4]=1)#[N:2].[N+:16]([C:19]1[CH:24]=[CH:23][C:22]([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)=[CH:21][CH:20]=1)([O-:18])=[O:17]>>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:14][CH2:13][CH:12]([N:28]3[CH2:29][CH2:30][N:25]([C:22]4[CH:21]=[CH:20][C:19]([N+:16]([O-:18])=[O:17])=[CH:24][CH:23]=4)[CH2:26][CH2:27]3)[CH2:11][CH2:10]2)=[CH:5][CH:4]=1)#[N:2]

참가 물질

반응물 2

HCID 804471-(4-Nitrophenyl)piperazine

HCID 110198874-(4-Oxopiperidin-1-yl)benzonitrile

생성물 1

HCID 23177844N-[1-(4-Cyanophenyl)-4-piperidinyl)-N'-(4-nitrophenyl)piperazine

실험 절차

2.5 g of 1-(4-cyanophenyl)-4-piperidone [cf. Taylor et al., Synthesis (1981) 606] and 5.2 g of 1-(4-nitrophenyl)piperazine were reacted as in Example 1.

출처 및 근거

ORD 기록: ord-b73968b5373d4c64a19f3b1b1b058d9c
출처 데이터셋: uspto-grants-1994_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05296485

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