Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
O-Xylene → 4-Propylpyridin-2-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | O-Xylene | HCID 7237 | — |
| 반응물 | Sodium amide | HCID 24533 | — |
| 반응물 | 4-Propylpyridine | HCID 70738 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 4-Propylpyridin-2-amine | HCID 7022594 | — |
반응 단계
75 g (0.62M) of 4-n-propylpyridine and 28 g (0.73M) of sodium amide were added to 250 ml of xylene, and the mixture was heated under reflux for 10 hr. Water was added in small portions to the reaction mixture under ice cooling to decompose excess sodium amide, and the reaction mixture was extracted with ethyl acetate, dried over magnesium sulfate and then purified by column chromatography (dichloromethanemethanol 50:1→20:1). The yield was 33 g. (blackish purple solid)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05298518 |
| 출처 데이터셋 | uspto-grants-1994_03 |
| ORD ID | ord-99275caca2504d5a8f8480478f041851 |
| 출처 메모 | uspto-grants-1994_03 |