Triethylamine → HCID 53975722, 화합물

HRID 488206

반응식

HRID 488206 반응식
[CH2:1]([N:13]=[C:14]=[O:15])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].N[CH2:17][C:18]1[CH:19]=[C:20]([Si:23]([CH2:28][CH3:29])([CH2:26][CH3:27])[CH2:24][CH3:25])[O:21][CH:22]=1.C([N:32](CC)CC)C>O1CCCC1>[CH2:1]([N:13]([CH2:17][C:18]1[CH:19]=[C:20]([Si:23]([CH2:24][CH3:25])([CH2:28][CH3:29])[CH2:26][CH3:27])[O:21][CH:22]=1)[C:14]([NH2:32])=[O:15])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 77873Dodecane, 1-isocyanato-HCID 150370494-Aminomethyl-2-triethylsilylfuran2회

생성물 1

HCID 53975722HCID 53975722, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Dodecylisocyanate (105 mg, 0.49 mmol) was added to a solution of 4-aminomethyl-2-triethylsilylfuran (Compound 2, 70 mg, 0.33 mmol) and triethylamine (69 microliter, 0.49 mmol) in tetrahydrofuran (3 ml) at room temperature. After stirring at room temperature overnight (ca. 16 hours), the reaction mixture was quenched with water. Extraction (ethyl ether) and evaporation of the dried (magnesium sulfate) extracts gave a residue which was purified by flash chromatography on silica using 60% ethyl ether/hexane. Fractions of Rf of about 0.47 on evaporation gave the title urea as an off-white solid.

후처리

  1. customthe reaction mixture was quenched with water
  2. extractionExtraction (ethyl ether) and evaporation of the
  3. dry with materialdried (magnesium sulfate)
  4. customextracts gave a residue which
  5. customwas purified by flash chromatography on silica using 60% ethyl ether/hexane
  6. customFractions of Rf of about 0.47 on evaporation

출처 및 근거

ORD 기록
ord-6f45c90fc71e4d249bd3d2476cc5cccf
출처 데이터셋
uspto-grants-1994_03
특허 번호
US05298633

연결된 노트

불러오는 중…