Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl 4-nitropyridine-2-carboxylate → Methyl 4-aminopyridine-2-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl 4-nitropyridine-2-carboxylate | HCID 3352523 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | Methyl 4-aminopyridine-2-carboxylate | HCID 3759117 | 94.1% |
반응 단계
A solution of methyl 4-nitropyridin-2-ylcarboxylate (0.7 g) (Deady et. al., Aus. J. Chem. 24 (1971)385-390) in methanol (30 ml) was treated with 10% Pd/C (0.3 g) and stirred under hydrogen at atmospheric pressure overnight. The solution was filtered and evaporated to yield the title compound (0.55 g). NMR δ(CDCl3) 3.97(3H,s), 4.34(2H, broad), 6.65(1H,dd), 7.39(1H,d), 8.32(1H,d).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06972297B2 |
| 출처 데이터셋 | uspto-grants-2005_12 |
| ORD ID | ord-7f1060c725a74a8e9560e611ae4b9716 |
| 출처 메모 | uspto-grants-2005_12 |