Methyl 4-nitropyridine-2-carboxylate → Methyl 4-aminopyridine-2-carboxylate

HRID 488454

반응식

HRID 488454 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][N:7]=[C:6]([C:10]([O:12][CH3:13])=[O:11])[CH:5]=1)([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:9]=[CH:8][N:7]=[C:6]([C:10]([O:12][CH3:13])=[O:11])[CH:5]=1

참가 물질

4

반응물 1

HCID 3352523Methyl 4-nitropyridine-2-carboxylate

생성물 1

HCID 3759117Methyl 4-aminopyridine-2-carboxylate수율 94.1%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A solution of methyl 4-nitropyridin-2-ylcarboxylate (0.7 g) (Deady et. al., Aus. J. Chem. 24 (1971)385-390) in methanol (30 ml) was treated with 10% Pd/C (0.3 g) and stirred under hydrogen at atmospheric pressure overnight. The solution was filtered and evaporated to yield the title compound (0.55 g). NMR δ(CDCl3) 3.97(3H,s), 4.34(2H, broad), 6.65(1H,dd), 7.39(1H,d), 8.32(1H,d).

후처리

  1. filtrationThe solution was filtered
  2. customevaporated

출처 및 근거

ORD 기록
ord-7f1060c725a74a8e9560e611ae4b9716
출처 데이터셋
uspto-grants-2005_12
특허 번호
US06972297B2

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