4-Ethynyl-1,1'-biphenyl → 2-Biphenyl-4-ylethynyl-3,5-dimethyl-3H-imidazole-4-carboxylic acid ethyl ester

반응식

[CH2:1]([O:3][C:4]([C:6]1[N:7]([CH3:13])[C:8](Br)=[N:9][C:10]=1[CH3:11])=[O:5])[CH3:2].[C:14]([C:16]1[CH:21]=[CH:20][C:19]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[CH:18][CH:17]=1)#[CH:15]>>[CH2:1]([O:3][C:4]([C:6]1[N:7]([CH3:13])[C:8]([C:15]#[C:14][C:16]2[CH:21]=[CH:20][C:19]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[CH:18][CH:17]=2)=[N:9][C:10]=1[CH3:11])=[O:5])[CH3:2]

참가 물질

반응물 2

HCID 344644-Ethynyl-1,1'-biphenyl

HCID 13897513ethyl 2-bromo-1,4-dimethyl-1H-imidazole-5-carboxylate

생성물 1

HCID 99027122-Biphenyl-4-ylethynyl-3,5-dimethyl-3H-imidazole-4-carboxylic acid ethyl ester

실험 절차

The title compound, MS: m/e=345.4 (M+H+) was prepared in accordance with the general method of example 1b from 2-bromo-3,5-dimethyl-3H-imidazole-4-carboxylic acid ethyl ester and 4-ethynylbiphenyl.

출처 및 근거

ORD 기록: ord-4da7d1ce6a3740339c0c0cec90ed760f
출처 데이터셋: uspto-grants-2005_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06972299B2

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