(4-Nitrophenyl)acetic acid → HCID 54348404, 화합물

반응식

[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11](O)=O)=[CH:6][CH:5]=1)([O-:3])=[O:2].[CH3:14][O:15][C:16]1[CH:17]=[C:18]([CH:21]=[C:22]([O:26][CH3:27])[C:23]=1[O:24][CH3:25])C=O.N1CCCCC1>>[CH3:27][O:26][C:22]1[CH:21]=[C:18]([CH:11]=[CH:10][C:7]2[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:9][CH:8]=2)[CH:17]=[C:16]([O:15][CH3:14])[C:23]=1[O:24][CH3:25]

참가 물질

반응물 3

HCID 4661(4-Nitrophenyl)acetic acid

HCID 68583,4,5-Trimethoxybenzaldehyde

HCID 8082Piperidine

생성물 1

HCID 54348404HCID 54348404, 화합물수율 41%

실험 절차

The title compound was prepared from p-nitrophenylacetic acid (18.6 g, 0.10 mol), 3,4,5-trimethoxy-benzaldehyde (19.6 g, 0.10 mol) and piperidine (5 mL) using the procedure described in Example 1, Step A. This procedure yielded a solid, 13.0 g (0.041 mol, 41%) of the desired product. mp: 192-195° C.

출처 및 근거

ORD 기록: ord-44781a1ff86b4f95844bd7c455d1a75c
출처 데이터셋: uspto-grants-2005_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06972287B1

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