Diethylamine → 4-[(Diethylamino)methyl]benzoic acid

HRID 488541

반응식

HRID 488541 반응식
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([OH:11])=[O:10])=[CH:5][CH:4]=1.[CH2:12]([NH:14][CH2:15][CH3:16])[CH3:13]>C(#N)C>[CH2:12]([N:14]([CH2:15][CH3:16])[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([OH:11])=[O:10])=[CH:5][CH:4]=1)[CH3:13]

참가 물질

4

반응물 2

HCID 8021DiethylamineHCID 742344-(Chloromethyl)benzoic acid

생성물 1

HCID 9485164-[(Diethylamino)methyl]benzoic acid수율 63%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

1 g (1 equivalent) of α-chloroparatoluic acid and 1.22 mL (2 equivalents) of diethylamine are placed in solution in 30 mL of acetonitrile. The reaction mixture is taken to reflux for 48 hours. The solvent is evaporated off under vacuum and the residue is purified by chromatography on silica gel column (CH2Cl2/MeOH 60/40 then pure MeOH). The product is obtained in the form of a white powder after precipitation from hexane. (Yield=63%).

후처리

  1. temperatureto reflux for 48 hours
  2. customThe solvent is evaporated off under vacuum
  3. customthe residue is purified by chromatography on silica gel column (CH2Cl2/MeOH 60/40
  4. customThe product is obtained in the form of a white powder
  5. customafter precipitation from hexane

출처 및 근거

ORD 기록
ord-67b3606ed97745088224a32eb7d53c20
출처 데이터셋
uspto-grants-2005_12
특허 번호
US06972343B1

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