methyl (2Z)-2-(acetylamino)-3-(4-amino-3-isopropylphenyl)acrylate → methyl N-acetyl-4-amino-3-isopropylphenylalaninate

HRID 488652노트

반응식

HRID 488652 반응식
[C:1]([NH:4]/[C:5](=[CH:10]\[C:11]1[CH:16]=[CH:15][C:14]([NH2:17])=[C:13]([CH:18]([CH3:20])[CH3:19])[CH:12]=1)/[C:6]([O:8][CH3:9])=[O:7])(=[O:3])[CH3:2].[H][H]>C(O)C.[Pd]>[C:1]([NH:4][C@H:5]([C:6]([O:8][CH3:9])=[O:7])[CH2:10][C:11]1[CH:16]=[CH:15][C:14]([NH2:17])=[C:13]([CH:18]([CH3:20])[CH3:19])[CH:12]=1)(=[O:3])[CH3:2]

참가 물질

5

반응물 2

HCID 86585325methyl (2Z)-2-(acetylamino)-3-(4-amino-3-isopropylphenyl)acrylateHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 69803103methyl N-acetyl-4-amino-3-isopropylphenylalaninate

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

methyl (2Z)-2-(acetylamino)-3-(4-amino-3-isopropylphenyl)acrylate (752 mg, 2.72 mmole) and 10% Pd/C (143 mg) stirred in ethanol (20 mL) under 1 atmosphere of hydrogen for 16 hours. The mixture was filtered through Celite and the filtrate was concentrated under reduced pressure to provide the titled compound.

후처리

  1. filtrationThe mixture was filtered through Celite
  2. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-40f018eea4dd47d8859cea3850569147
출처 데이터셋
uspto-grants-2005_12
특허 번호
US06972340B2

반응 노트

불러오는 중…