Bromine → 2-(2-Amino-5-bromo-phenyl)-ethanol

HRID 488654노트

반응식

HRID 488654 반응식
[NH2:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[CH2:4][CH2:5][OH:6].[Br:11]Br>C(O)(=O)C>[NH2:1][C:2]1[CH:10]=[CH:9][C:8]([Br:11])=[CH:7][C:3]=1[CH2:4][CH2:5][OH:6]

참가 물질

4

반응물 2

HCID 24408BromineHCID 79282o-Aminophenethyl alcohol

생성물 1

HCID 219968352-(2-Amino-5-bromo-phenyl)-ethanol수율 100.3%

시약·촉매·용매 1

HCID 176Acetic Acid용매3회

실험 절차

To a solution of 2-aminophenethyl alcohol (10.0 g, 72.9 mmol) in acetic acid (60 mL) at 10° C. was added Br2 (3.8 mL, 72.9 mmol) in acetic acid (5 mL). Additional acetic acid (30 mL) was added and the reaction was stirred for 1 hour. The mixture was filtered and the filter cake washed with diethyl ether. The solid was then partitioned between ethyl acetate and aqueous 3N NaOH. The organic layer was washed with brine, dried (Na2SO4), filtered and concentrated under reduced pressure to provide the titled compound (15.8 g).

후처리

  1. filtrationThe mixture was filtered
  2. washthe filter cake washed with diethyl ether
  3. customThe solid was then partitioned between ethyl acetate and aqueous 3N NaOH
  4. washThe organic layer was washed with brine
  5. dry with materialdried (Na2SO4)
  6. filtrationfiltered
  7. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-08e4b1d43a0b4c74983299ec1bcc6281
출처 데이터셋
uspto-grants-2005_12
특허 번호
US06972340B2

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