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Sodium Carbonate → 3-Bromo-5-(3,4-dichlorophenyl)-4-amino-pyridine

HRID 488721
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인쇄 미리보기

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HRID 488721 반응식
Br[C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Br:9])[C:7]=1[NH2:8].C([O-])([O-])=O.[Na+].[Na+].[Cl:16][C:17]1[C:18]([Cl:26])=[C:19](B(O)O)[CH:20]=[CH:21][CH:22]=1>C1(C)C=CC=CC=1.C(O)C.C(OCC)(=O)C.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[Br:9][C:6]1[CH:5]=[N:4][CH:3]=[C:2]([C:20]2[CH:21]=[CH:22][C:17]([Cl:16])=[C:18]([Cl:26])[CH:19]=2)[C:7]=1[NH2:8]
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참가 물질

8

반응물 3

HCID 10340Sodium CarbonateHCID 6197924-Amino-3,5-dibromopyridineHCID 27346612,3-Dichlorobenzeneboronic acid

생성물 1

HCID 222673173-Bromo-5-(3,4-dichlorophenyl)-4-amino-pyridine

시약·촉매·용매 4

HCID 178418397HCID 178418397, 화합물촉매
HCID 702
Ethanol
용매
HCID 1140Toluene용매
HCID 8857Ethyl Acetate용매

실험 절차

A solution of 3,5-dibromo-4-amino-pyridine 1 (4.0 g, 15.87 mmol), Pd(PPh3)4 (0.91 g, 0.78 mmol) and aqueous solution of Na2CO3 (23.8 ml, 2M) in toluene (80 ml) is added to a solution of dichlorobenzene boronic acid (6.23 g, 46.4 mmole) in ethanol (24 ml). The mixture is refluxed for 14 h., diluted with ethyl acetate and washed with saturated NH4Cl solution. The organic layer is dried over sodium sulfate and concentrated in vacuo. The residue is chromatographed on silica gel to give 2.

후처리

  1. temperatureThe mixture is refluxed for 14 h.
  2. washwashed with saturated NH4Cl solution
  3. dry with materialThe organic layer is dried over sodium sulfate
  4. concentrationconcentrated in vacuo
  5. customThe residue is chromatographed on silica gel
  6. customto give 2

출처 및 근거

ORD 기록
ord-0b5ac5e1d3264deeb2e49a2f83b3b173
출처 데이터셋
uspto-grants-2005_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06974808B2

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