Cyclohexane → 3-(3-bromopropyl)-1H-indole

HRID 488762

반응식

HRID 488762 반응식
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH2:10][CH2:11][CH2:12]O)=[CH:2]1.[Br:14]P(Br)(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.C1CCCCC1>O1CCOCC1>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH2:10][CH2:11][CH2:12][Br:14])=[CH:2]1

참가 물질

5

반응물 3

HCID 8078CyclohexaneHCID 70579Triphenylphosphine dibromideHCID 77115Indole-3-propanol

생성물 1

HCID 100371923-(3-bromopropyl)-1H-indole수율 99.4%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

To a solution of 2 g (11.41 mmol) of 3-(1H-indol-3-yl)propanol in 40 ml of dioxane was added at room temperature 5.3 g (12.55 mmol) of dibromotriphenylphosphorane and the resulting solution was stirred during 18 h. An excess of cyclohexane was added and the resulting precipitate was filtered and discarded. The solvent was evaporated to dryness to give 2.7 g (99%) of product as an oil which was used in the subsequent step without further purification.

후처리

  1. filtrationthe resulting precipitate was filtered
  2. customThe solvent was evaporated to dryness

출처 및 근거

ORD 기록
ord-eeb14de8206a4951914cf43bcae514b2
출처 데이터셋
uspto-grants-2005_12
특허 번호
US06974819B2

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