Bromine → 2-Bromo-1,3-diphenyl-1-propanone

HRID 488770

반응식

HRID 488770 반응식
[C:1]1([C:7](=[O:16])[CH2:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:17]Br>O1CCOCC1>[Br:17][CH:8]([CH2:9][C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1)[C:7]([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)=[O:16]

참가 물질

4

반응물 2

HCID 24408BromineHCID 64802Dihydrochalcone2회

생성물 1

HCID 30396872-Bromo-1,3-diphenyl-1-propanone

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

To a solution of 1,3-diphenylpropan-1-one (compound 2) (7.0 mmol) in 25 ml of anhydrous dioxane, a solution of bromine (7.0 mmol) in 10 ml of dioxane was slowly added dropwise over 30 min. The reaction mixture was left to stir at room temperature for 24 hrs to form 2-bromo-1,3-diphenylpropan-1-one (compound 3). Solvent was removed in vacuo. The 2-bromo-1,3-diphenylpropan-1-one product formed was determined by 1H NMR to be sufficiently pure to be used in the next step.

후처리

  1. waitThe reaction mixture was left

출처 및 근거

ORD 기록
ord-7893031004964d65825ebce55d7a7866
출처 데이터셋
uspto-grants-2005_12
특허 번호
US06974830B2

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