Potassium Hydroxide → 2-Phenylisobutyric acid

HRID 488771

반응식

HRID 488771 반응식
C[O:2][C:3](=[O:13])[C:4]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)([CH3:6])[CH3:5].[OH-].[K+]>CO.O>[CH3:6][C:4]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)([CH3:5])[C:3]([OH:13])=[O:2]

참가 물질

5

반응물 2

HCID 14797Potassium HydroxideHCID 143498Methyl 2-methyl-2-phenylpropanoate

생성물 1

HCID 132222-Phenylisobutyric acid수율 87%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

A solution of 0.10 mole (1 eq.) of α,α-dimethylphenylacetic acid methyl ester 2 in 150 mL of MeOH and 50 mL of water was added 1.02 mole (10. 1 eq.) of KOH pellets. After stirring at room temperature for 3.5 days, the methanol was stripped off by rotary evaporation. To the residual liquid was added 100 mL of water and enough concentrated HCl to bring to ˜pH 3. The aqueous solution was extracted with Et2O (3×100 mL). The combined organic layers were dried over MgSO4 and vacuum filtered. The filtrate was rotary evaporated and dried under vacuum to give a white solid as α,α-dimethylphenylacetic acid 3 (87-89%). Method D

후처리

  1. customthe methanol was stripped off by rotary evaporation
  2. additionTo the residual liquid was added 100 mL of water and enough concentrated HCl
  3. extractionThe aqueous solution was extracted with Et2O (3×100 mL)
  4. dry with materialThe combined organic layers were dried over MgSO4 and vacuum
  5. filtrationfiltered
  6. customThe filtrate was rotary evaporated
  7. customdried under vacuum

출처 및 근거

ORD 기록
ord-95ad98fa9eab4faf904f0941593e639e
출처 데이터셋
uspto-grants-2005_12
특허 번호
US06974829B2

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