Cesium carbonate → HCID 69733830, 화합물

HRID 488780노트

반응식

HRID 488780 반응식
[Br:1][C:2]1[N:11]=[C:10]2[C:5]([CH:6]=[C:7]([OH:12])[N:8]=[CH:9]2)=[CH:4][CH:3]=1.Br[CH2:14][C:15]1[CH:24]=[CH:23][C:18]([C:19]([O:21][CH3:22])=[O:20])=[CH:17][CH:16]=1.C(=O)([O-])[O-].[Cs+].[Cs+]>CN(C)C=O>[CH3:22][O:21][C:19](=[O:20])[C:18]1[CH:23]=[CH:24][C:15]([CH2:14][N:8]2[C:7](=[O:12])[CH:6]=[C:5]3[C:10]([N:11]=[C:2]([Br:1])[CH:3]=[CH:4]3)=[CH:9]2)=[CH:16][CH:17]=1

참가 물질

5

반응물 3

HCID 10796Cesium carbonateHCID 256687Methyl 4-(bromomethyl)benzoateHCID 178515313HCID 178515313, 화합물

생성물 1

HCID 69733830HCID 69733830, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

The alkylation of 7-bromo-3-hydroxy-8-azaisoquinoline (1.00 g, 4.46 mmol) using methyl 4-(bromomethyl)benzoate (1.53 g, 6.69 mmol) and cesium carbonate (2.18 g, 6.69 mmol) in dimethylformamide is carried out as previously described in Example 1, Step (1). The solid is crystallized from hexanes/ethyl acetate 2:1, the white crystals collected by filtration and dried to give the desired product.

후처리

  1. customThe solid is crystallized from hexanes/ethyl acetate 2:1
  2. filtrationthe white crystals collected by filtration
  3. customdried

출처 및 근거

ORD 기록
ord-427f53e318c34bf0a1268facf5fb49fb
출처 데이터셋
uspto-grants-2005_12
특허 번호
US06974822B2

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