참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 2,4-Heptanedione, 6-methyl- | HCID 76354 | — |
| 반응물 | 2-Cyanoethanethioamide | HCID 1416277 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | HCID 178425008 | HCID 178425008 | 61.7% |
반응 단계
To a stirred solution of cyanothioacetamide (2.20 g, 22 mmol) and 6-methyl-2,4-heptanedione (3.12 g, 22 mmol) in anhydrous EtOH (40 ML) was added triethylamine (0.4 mL) and the reaction was heated at 50° C. for 1 h before it was allowed to cool to room temperature. Filtration and washing of the precipitates with EtOH gave 6-isobutyl-2-mercapto-4-methylnicotinonitrile as a yellow solid (2.8 g, 61%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06974870B2 |
|---|
| 출처 데이터셋 | uspto-grants-2005_12 |
|---|
| ORD ID | ord-a142c28b97a546368f8a82ace5b32b7a |
|---|
| 출처 메모 | uspto-grants-2005_12 |
|---|
