2-Bromoacetamide → 3-Amino-4,6-dimethylthieno(2,3-b)pyridine-2-carboxamide
반응식
Br[CH2:2][C:3]([NH2:5])=[O:4].[SH:6][C:7]1[N:14]=[C:13]([CH3:15])[CH:12]=[C:11]([CH3:16])[C:8]=1[C:9]#[N:10].C[O-].[Na+]>CO>[NH2:10][C:9]1[C:8]2[C:7](=[N:14][C:13]([CH3:15])=[CH:12][C:11]=2[CH3:16])[S:6][C:2]=1[C:3]([NH2:5])=[O:4]참가 물질
5
실험 절차
α-Bromoacetamide (388 mg, 2.81 mmol) was added to a solution of 2-mercapto-4,6-dimethyl-nicotinonitrile (420 mg, 2.56 mmol) in MeOH (25 mL) at room temperature. This was followed by addition of sodium methoxide (1.76 mL, 25% NaOMe in MeOH, 7.7 mmol). The reaction mixture was heated to reflux. Heating at reflux was continued overnight, after which time the reaction mixture was cooled and filtered. The product was dried overnight providing 450 mg (80%) of the title compound, m.p. 238-40° C.
후처리
- temperatureThe reaction mixture was heated to reflux
- temperatureHeating
- temperatureat reflux
- temperatureafter which time the reaction mixture was cooled
- filtrationfiltered
- customThe product was dried overnight
출처 및 근거
- ORD 기록
- ord-1f2adbfdf41b4220ad40b94de5d3222a
- 출처 데이터셋
- uspto-grants-2005_12
- 특허 번호
- US06974870B2
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