참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 반응물 | FMOC-L-valine | HCID 688217 | — |
| 반응물 | Benzyl 4,5-dihydroxy-2-pentenoate | HCID 54529065 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Benzyl 5-(N-FMOC-L-valyloxy)-4-hydroxy-2-pentenoate | HCID 54039988 | — |
반응 단계
A mixture of benzyl 4,5-dihydroxy-2-pentenoate (4.4 g, 20 mmole), N-FMOC-L-valine (5.8 g, 17 mmole) and DMAP (0.21 g, 1.7 mmole) in 100 ml dichloromethane was cooled to about 10° C. A solution of DCC (4.2 g, 20 mmole) in 25 ml dichloromethane was added dropwise at the same temperature and the mixture was stirred overnight at room temperature. The mixture was cooled to 5° C. and the urethane was filtered. The filtrate was evaporated under reduced pressure and the product was isolated by silica gel column chromatography.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06974802B2 |
|---|
| 출처 데이터셋 | uspto-grants-2005_12 |
|---|
| ORD ID | ord-2bd9dcf911874b48baa6e271c7418ec1 |
|---|
| 출처 메모 | uspto-grants-2005_12 |
|---|
