Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dicyclohexylcarbodiimide → benzyl-2-(N-FMOC-L-valyloxy)stearate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 반응물 | FMOC-L-valine | HCID 688217 | — |
| 반응물 | Benzyl 2-hydroxystearate | HCID 22035791 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | benzyl-2-(N-FMOC-L-valyloxy)stearate | HCID 23387558 | — |
반응 단계
To a solution of benzyl-2-hydroxystearate (3.2 g, 8.2 mmole), N-FMOC-L-valine (3.4 g, 10 mmole) and DMAP (0.12 g, 1 mmole) in 80 ml dichloromethane was added a solution of DCC (2.5 g, 12 mmole) and the mixture was stirred overnight at room temperature. The mixture was cooled to 5° C. and the urethane was filtered. The filtrate was evaporated and the product was isolated by silica gel column chromatography. Yield: 4.5 g
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06974802B2 |
| 출처 데이터셋 | uspto-grants-2005_12 |
| ORD ID | ord-55e6eab99dea4777903a31eabdd16b09 |
| 출처 메모 | uspto-grants-2005_12 |