4-[1-oxo-7-(3-[1,2,4]Triazol-1-ylprop-1-ynyl)-1H-3,5,8-triazaisoquinolin-2-ylmethyl]benzoic Acid tert-Butyl Ester → 4-[1-oxo-7-(3-[1,2,4]Triazol-1-ylprop-1-ynyl)-1H-3,5,8-triazaisoquinolin-2-ylmethyl]benzoic Acid

HRID 489190노트

반응식

HRID 489190 반응식
C([O:5][C:6](=[O:33])[C:7]1[CH:12]=[CH:11][C:10]([CH2:13][N:14]2[N:23]=[CH:22][C:21]3[C:16](=[N:17][C:18]([C:24]#[C:25][CH2:26][N:27]4[CH:31]=[N:30][CH:29]=[N:28]4)=[CH:19][N:20]=3)[C:15]2=[O:32])=[CH:9][CH:8]=1)(C)(C)C>FC(F)(F)C(O)=O>[O:32]=[C:15]1[C:16]2[C:21](=[N:20][CH:19]=[C:18]([C:24]#[C:25][CH2:26][N:27]3[CH:31]=[N:30][CH:29]=[N:28]3)[N:17]=2)[CH:22]=[N:23][N:14]1[CH2:13][C:10]1[CH:11]=[CH:12][C:7]([C:6]([OH:33])=[O:5])=[CH:8][CH:9]=1

참가 물질

3

반응물 1

HCID 104111454-[1-oxo-7-(3-[1,2,4]Triazol-1-ylprop-1-ynyl)-1H-3,5,8-triazaisoquinolin-2-ylmethyl]benzoic Acid tert-Butyl Ester

생성물 1

HCID 222652984-[1-oxo-7-(3-[1,2,4]Triazol-1-ylprop-1-ynyl)-1H-3,5,8-triazaisoquinolin-2-ylmethyl]benzoic Acid

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

A solution of 4-[1-oxo-7-(3-[1,2,4]triazol-1-ylprop-1-ynyl)-1H-3,5,8-triazaisoquinolin-2-ylmethyl]benzoic acid tert-butyl ester (0.46 g, 1.04 mmol, Example 15A) is treated with trifluoroacetic acid (10 mL) and stirred at room temperature for 40 minutes. The reaction mixture is evaporated to dryness, triturated with ethyl acetate, the solid is collected by filtration, washed with water, washed with ethyl acetate, and dried under house vacuum. This will afford the desired product.

후처리

  1. customThe reaction mixture is evaporated to dryness
  2. customtriturated with ethyl acetate
  3. filtrationthe solid is collected by filtration
  4. washwashed with water
  5. washwashed with ethyl acetate
  6. customdried under house vacuum

출처 및 근거

ORD 기록
ord-2cc3e9b88c184c3c9dd6dbd5d9b44078
출처 데이터셋
uspto-grants-2005_12
특허 번호
US06977261B2

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