Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dehydroepiandrosterone → Dehydroepiandrosterone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dehydroepiandrosterone | HCID 5881 | — |
| 반응물 | 22,29-EPOXY-3,29-DIHYDROXY-14beta-STIGMASTAN-15-ONE | HCID 69625815 | — |
| 생성물 | Dehydroepiandrosterone | HCID 5881 | — |
| 생성물 | HCID 178420941 | HCID 178420941 | — |
반응 단계
The synthesis of 22,29-epoxy-3,29-dihydroxy-14β-stigmastan-15-one (260) can be accomplished in ten steps from dehydroisoandrosterone (247). Catalytic hydrogenation of the Δ5 carbon-carbon double bond in compound 247 yields compound 250, which contains a trans-fused A/B ring-system. Compound 247 is dissolved in EtOAc and 10% Pd/C is added. The mixture is stirred under H2 at room temperature overnight. Filtration through celite and concentration yields compound 250, which can be used directly in the next reaction.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06706701B1 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-d863766c08014899a9c4dffcca1796e9 |
| 출처 메모 | uspto-grants-2004_03 |