Potassium Carbonate → 3-Allyl-5-[(2-chloro-4-fluorophenoxy)methyl]-1,2,4-oxadiazole

HRID 4896

반응식

HRID 4896 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[OH:9].[CH2:10]([C:13]1[N:17]=[C:16]([CH2:18]Cl)[O:15][N:14]=1)[CH:11]=[CH2:12].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH2:10]([C:13]1[N:17]=[C:16]([CH2:18][O:9][C:3]2[CH:4]=[CH:5][C:6]([F:8])=[CH:7][C:2]=2[Cl:1])[O:15][N:14]=1)[CH:11]=[CH2:12]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 748142-Chloro-4-fluorophenolHCID 197971305-(Chloromethyl)-3-(prop-2-en-1-yl)-1,2,4-oxadiazole

생성물 1

HCID 197971293-Allyl-5-[(2-chloro-4-fluorophenoxy)methyl]-1,2,4-oxadiazole수율 80.8%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

0.71 g of 2-chloro-4-fluorophenol, 0.77 g of 3-allyl-5-chloromethyl-1,2,4-oxadiazole and 0.83 of potassium carbonate were added to 20 ml of acetone. After completion of the reaction, the resulting precipitates were filtered out from the mixture and then acetone was removed by distillation, and the residue was purified by column chromatography (benzene:hexane=1:1) to obtain 1.05 g of the desired product(yield: 80.8%).

후처리

  1. customAfter completion of the reaction
  2. customthe resulting precipitates
  3. filtrationwere filtered out from the mixture
  4. customacetone was removed by distillation
  5. customthe residue was purified by column chromatography (benzene:hexane=1:1)

출처 및 근거

ORD 기록
ord-78085214e0d5496ab614bdad6a715709
출처 데이터셋
uspto-grants-1993_09
특허 번호
US05242890

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