Potassium Carbonate → 3-Allyl-5-[(2-chloro-4-fluorophenoxy)methyl]-1,2,4-oxadiazole
반응식
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[OH:9].[CH2:10]([C:13]1[N:17]=[C:16]([CH2:18]Cl)[O:15][N:14]=1)[CH:11]=[CH2:12].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH2:10]([C:13]1[N:17]=[C:16]([CH2:18][O:9][C:3]2[CH:4]=[CH:5][C:6]([F:8])=[CH:7][C:2]=2[Cl:1])[O:15][N:14]=1)[CH:11]=[CH2:12]참가 물질
5
실험 절차
0.71 g of 2-chloro-4-fluorophenol, 0.77 g of 3-allyl-5-chloromethyl-1,2,4-oxadiazole and 0.83 of potassium carbonate were added to 20 ml of acetone. After completion of the reaction, the resulting precipitates were filtered out from the mixture and then acetone was removed by distillation, and the residue was purified by column chromatography (benzene:hexane=1:1) to obtain 1.05 g of the desired product(yield: 80.8%).
후처리
- customAfter completion of the reaction
- customthe resulting precipitates
- filtrationwere filtered out from the mixture
- customacetone was removed by distillation
- customthe residue was purified by column chromatography (benzene:hexane=1:1)
출처 및 근거
- ORD 기록
- ord-78085214e0d5496ab614bdad6a715709
- 출처 데이터셋
- uspto-grants-1993_09
- 특허 번호
- US05242890
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