Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Acid → 4-Amino-5-fluoro-2-(3-methylpicolinoyl)phenyl thiocyanate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Bromine | HCID 24408 | — |
| 반응물 | Sodium thiocyanate | HCID 516871 | — |
| 반응물 | 3-Amino-4-fluorophenyl 3-methyl-2-pyridyl ketone | HCID 12056833 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 4-Amino-5-fluoro-2-(3-methylpicolinoyl)phenyl thiocyanate | HCID 11196957 | 100% |
반응 단계
To a mixture of 3-amino-4-fluorophenyl 3-methyl-2-pyridyl ketone(4.20 g, 0.171 mol), sodium thiocyanate (4.19 g, 0.0517 mol) and glacial acetic acid is added a solution of bromine in acetic acid (2M, 12 ml, 0.0240 mol) over a one hour period. The resultant mixture is stirred one hour at room temperature and poured into cold water. The precipitate is filtered and dried to afford the title compound as a green solid (5.43 g, >100%) which is identified by NMR and mass spectral analysis.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06706663B2 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-19a20f7f68d44d88ab8d02b254a6f989 |
| 출처 메모 | uspto-grants-2004_03 |