Ammonium Hydroxide → 5-Amino-6-fluoro-3-(3-methyl-2-pyridyl)-1,2-benzisothiazole
반응식
[NH2:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([S:9]C#N)=[C:4]([C:12](=O)[C:13]2[C:18]([CH3:19])=[CH:17][CH:16]=[CH:15][N:14]=2)[CH:3]=1.[OH-].[NH4+:22]>CO>[NH2:1][C:2]1[C:7]([F:8])=[CH:6][C:5]2[S:9][N:22]=[C:12]([C:13]3[C:18]([CH3:19])=[CH:17][CH:16]=[CH:15][N:14]=3)[C:4]=2[CH:3]=1참가 물질
4
실험 절차
A mixture of 4-amino-5-fluoro-2-(3-methylpicolinoyl)phenyl thiocyanate(3.06 g, 0.0112 mole), concentrated ammonium hydroxide (300 ml) and methanol (300 ml) is stirred overnight at room temperature. The methanol is removed in vacuo and the resultant mixture is filtered to afford the title compound as a green solid (1.93 g, 66.6%) which is identified by NMR spectral analysis.
후처리
- customThe methanol is removed in vacuo
- filtrationthe resultant mixture is filtered
출처 및 근거
- ORD 기록
- ord-315bbe081a5247e9bd79bf30d08c872f
- 출처 데이터셋
- uspto-grants-2004_03
- 특허 번호
- US06706663B2
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