Isobutyl iodide → 1-(6-Amino-5-chloro-2-methoxy-3-pyridinyl)-3-(1-isobutyl-4-piperidinyl)-1-propanone

HRID 489802노트

반응식

HRID 489802 반응식
[NH2:1][C:2]1[N:7]=[C:6]([O:8][CH3:9])[C:5]([C:10](=[O:19])[CH2:11][CH2:12][CH:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)=[CH:4][C:3]=1[Cl:20].I[CH2:22][CH:23]([CH3:25])[CH3:24].NC1N=C(OC)C(C(=O)CCC2CCNCC2)=CC=1.ICCCC>>[NH2:1][C:2]1[N:7]=[C:6]([O:8][CH3:9])[C:5]([C:10](=[O:19])[CH2:11][CH2:12][CH:13]2[CH2:18][CH2:17][N:16]([CH2:22][CH:23]([CH3:25])[CH3:24])[CH2:15][CH2:14]2)=[CH:4][C:3]=1[Cl:20]

참가 물질

5

반응물 4

HCID 10556Isobutyl iodideHCID 10962Butyl iodideHCID 222625871-(6-Amino-5-chloro-2-methoxy-3-pyridinyl)-3-(4-piperidinyl)-1-propanoneHCID 222626571-(6-Amino-2-methoxy-3-pyridinyl)-3-(4-piperidinyl)-1-propanone

생성물 1

HCID 102154991-(6-Amino-5-chloro-2-methoxy-3-pyridinyl)-3-(1-isobutyl-4-piperidinyl)-1-propanone

실험 절차

The title compound was prepared according to the procedure of step 2 in the example 13 using 1-(6-amino-5-chloro-2-methoxy-3-pyridinyl)-3-(4-piperidinyl)-1-propanone and 1-iodo-2-methylpropane, instead of 1-(6-amino-2-methoxy-3-pyridinyl)-3-(4-piperidinyl)-1-propanone and 1-iodobutane.

출처 및 근거

ORD 기록
ord-b3d1e4b01a3a492fb4e580e371c8872d
출처 데이터셋
uspto-grants-2005_12
특허 번호
US06979690B2

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