4,4'-Dimethoxydiphenylamine → 4-Methoxy-N-(4-methoxyphenyl)-N-phenylaniline

HRID 489869

반응식

HRID 489869 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10]2[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=2)=[CH:5][CH:4]=1.I[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.C(O[Na])(C)(C)C>C1(C)C(C)=CC=CC=1>[CH3:17][O:16][C:13]1[CH:14]=[CH:15][C:10]([N:9]([C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=2)[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[CH:11][CH:12]=1

참가 물질

5

반응물 3

HCID 75714,4'-DimethoxydiphenylamineHCID 11575IodobenzeneHCID 178418730sodium 2-methylpropan-2-olate

생성물 1

HCID 105430434-Methoxy-N-(4-methoxyphenyl)-N-phenylaniline

시약·촉매·용매 1

HCID 7237O-Xylene용매

실험 절차

1.00 g (4.46 mmols) of N,N-di(4-methoxyphenyl)amine (31a), 1.00 g (4.90 mmols) of iodobenzene (32a), 0.502 g (5.23 mmols) of t-BuONa and 0.010 g (0.044 mmols) of Pd(CH3COO)2 were dissolved in anhydrous xylene, and while refluxing the solution in an atmosphere of nitrogen, 1.0 ml of 0.237 M of P(But)3 was further dropped, followed by refluxing for 4 hours.

후처리

  1. temperaturewhile refluxing the solution in an atmosphere of nitrogen, 1.0 ml of 0.237 M of P(But)3
  2. additionwas further dropped
  3. temperatureby refluxing for 4 hours

출처 및 근거

ORD 기록
ord-1c9b7ed7850a4341956aa0d649b0ad8a
출처 데이터셋
uspto-grants-2005_12
특허 번호
US06979746B2

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