참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2-Phenylglycine | HCID 3866 | — |
| 반응물 | N-Methylbenzylamine | HCID 7669 | — |
| 반응물 | 2-(((Tert-butoxy)carbonyl)amino)-2-phenylacetic acid | HCID 571805 | — |
| 반응물 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 반응물 | 1-Hydroxybenzotriazole hydrate | HCID 2796029 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | tert-butyl (RS)-2-[benzyl(methyl)amino]-2-oxo-1-phenylethylcarbamate | HCID 53439138 | — |
반응 단계
In another example of a process for preparing a compound of formula C, where R6 is methyl and R7 is benzyl, (RS)-N-tert-butoxycarbonyl-2-phenylglycine, commercially available or prepared from (RS)-2-phenylglycine using methods well known in the art, is combined with 1-hydroxybenzotriazole hydrate, commercially available N-methylbenzylamine and N-[3-(dimethylamino)propyl-N′-ethylcarbodimide hydrochloride in dichloromethane and the resulting mixture stirred for about 24 hours. The resulting mixture is subjected to an aqueous work-up similar to that described above, providing (tert-butyl (RS)-2-[benzyl(methyl)amino]-2-oxo-1-phenylethylcarbamate, which may be treated with trifluorocaetic acid and triethylsilane in dichloromethane, followed by aqueous workup to yield (RS)-N-benzyl-N-methyl-2-phenylglycinamide.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US06979692B2 |
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| 출처 데이터셋 | uspto-grants-2005_12 |
|---|
| ORD ID | ord-2cefb3b74d924722af2b728a627c7fe9 |
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| 출처 메모 | uspto-grants-2005_12 |
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