4,4'-Difluorobenzophenone → (4-Aminophenyl)(4-fluorophenyl)methanone

HRID 490015노트

반응식

HRID 490015 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)([OH:11])C#C)=[CH:4][CH:3]=1.FC1C=CC(C(C2C=CC(F)=CC=2)=O)=CC=1>>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)=[O:11])=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 95824,4'-DifluorobenzophenoneHCID 876134721-(4-Aminophenyl)-1-(4-fluorophenyl)-2-propyn-1-ol

생성물 1

HCID 577826(4-Aminophenyl)(4-fluorophenyl)methanone

실험 절차

Referring now to FIG. 2, wherein one non-limiting approach to the 1-(4-aminophenyl)-1-(4-fluorophenyl)-2-propyn-1-ol is presented, 4,4′-difluorobenzophenone (7) is reacted with a secondary amine HNR′″R″″ to give the 4-amino-4′-fluorobenzophenone 8, where R′″ and R″″ may be the same as R36 and R37, respectively, as set forth and claimed herein. Acetylide anion, for example, sodium acetylide in acetylene saturated dimethylformamide, is added to the carbonyl of 4-amino-4′-fluorobenzophenone 8 to give, upon aqueous workup, 1-(4-aminophenyl)-1-(4-fluorophenyl)-2-propyn-1-ol 9.

출처 및 근거

ORD 기록
ord-bc6840b61a2f47df85eb97f708fd6de6
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07527754B2

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