(4-Aminophenyl)(4-fluorophenyl)methanone → 1-(4-Aminophenyl)-1-(4-fluorophenyl)-2-propyn-1-ol

HRID 490016노트

반응식

HRID 490016 반응식
[C-:1]#[C-:2].[C-]#[C-].[Na+].[Na+].[NH2:7][C:8]1[CH:22]=[CH:21][C:11]([C:12]([C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=2)=[O:13])=[CH:10][CH:9]=1>C#C>[NH2:7][C:8]1[CH:22]=[CH:21][C:11]([C:12]([C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=2)([OH:13])[C:1]#[CH:2])=[CH:10][CH:9]=1

참가 물질

5

반응물 3

HCID 577826(4-Aminophenyl)(4-fluorophenyl)methanone2회HCID 178420940HCID 178420940, 화합물HCID 178463197HCID 178463197, 화합물

생성물 1

HCID 876134721-(4-Aminophenyl)-1-(4-fluorophenyl)-2-propyn-1-ol

시약·촉매·용매 1

HCID 6326Acetylene용매

실험 절차

Referring now to FIG. 2, wherein one non-limiting approach to the 1-(4-aminophenyl)-1-(4-fluorophenyl)-2-propyn-1-ol is presented, 4,4′-difluorobenzophenone (7) is reacted with a secondary amine HNR′″R″″ to give the 4-amino-4′-fluorobenzophenone 8, where R′″ and R″″ may be the same as R36 and R37, respectively, as set forth and claimed herein. Acetylide anion, for example, sodium acetylide in acetylene saturated dimethylformamide, is added to the carbonyl of 4-amino-4′-fluorobenzophenone 8 to give, upon aqueous workup, 1-(4-aminophenyl)-1-(4-fluorophenyl)-2-propyn-1-ol 9.

출처 및 근거

ORD 기록
ord-1a5dcfb5600647a4b7ac5e22e5269b9e
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07527754B2

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