Ethyl bromoacetate → 3-Hydroxy-5-phenoxypentanoic acid

HRID 490026노트

반응식

HRID 490026 반응식
[O:1]([CH2:8][CH2:9][CH:10]=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:13][C:14]([O:16]CC)=[O:15]>>[OH:11][CH:10]([CH2:9][CH2:8][O:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[CH2:13][C:14]([OH:16])=[O:15]

참가 물질

3

반응물 2

HCID 7748Ethyl bromoacetateHCID 109864123-Phenoxypropanal

생성물 1

HCID 220240393-Hydroxy-5-phenoxypentanoic acid

실험 절차

Magnetic microcapsules 31 were obtained in the same manner as in Example 25 except that the purified enzyme solution (1) in Example 25 was replaced by the crude enzyme solution (3) and (R)-3-hydroxybutyryl CoA was replaced by (R,S)-3-hydroxy-5-phenoxyvaleryl CoA (prepared by hydrolyzing 3-hydroxy-5-phenoxy valerate obtained through a Reformatsky reaction with zinc using 3-phenoxypropanal and ethyl bromoacetate as raw materials, which were synthesized according to a procedure described in J. Org. Chem., 55, 1490-1492, 1990, to produce 3-hydroxy-5-phenoxy valeric acid and then following a procedure described in Eur. J. Biochem., 250, 432-439, 1997). The drug content in the microcapsules is shown in Table 5

후처리

  1. customwere synthesized

출처 및 근거

ORD 기록
ord-7a3310b9de2747c6b8d46d4fede6512e
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07527809B2

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